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Advances in type 2 diabetes drugs

first_imgResearchers from Harvard-affiliated Dana-Farber Cancer Institute and the Scripps Research Institute in Jupiter, Fla., report they have created prototype drugs having powerful anti-diabetic effects, yet apparently free — at least in mice — of dangerous side effects plaguing some current diabetes medications.The researchers say that their “proof-of-principle” findings could lead to safer medications for type 2 diabetes, which affects more than 25 million children and adults in the United States. Their findings are being published Sept. 4 by the journal Nature as an advanced online publication and later in a print edition.One of the drug prototypes proved capable of reducing disease symptoms in diabetes-prone mice without triggering weight gain or fluid retention, potential side effects of current drugs such as rosiglitazone (Avandia) and pioglitazone (Actos) that can have had fatal consequences in some patients.Bruce Spiegelman of Dana-Farber and Patrick Griffin of Scripps led the scientific group that developed a series of related compounds and tested them in overfed and genetically obese mice. While these novel compounds would not be suitable for use in human patients, the scientists say the results showed that they had succeeded in building selective anti-diabetic molecules that minimize the risk of severe side effects.“This insight shows how you can make new compounds that appear to be safer, but you don’t know for sure until a drug is developed that you can give to patients,” says Spiegelman, the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at Harvard Medical School.Avandia and Actos are members of a drug class called thiazolidinediones (TZD) that have proven to be effective, oral diabetes drugs and are well tolerated by most patients. In a minority of patients, however, Avandia and Actos have been linked to cardiac complications, including fatal heart attacks and loss of bone density. The drugs are under close scrutiny by federal regulators, and are prescribed cautiously by physicians.TZD drugs target a metabolic “master regulator” of fat cell development, called PPAR-gamma, which is a transcription factor controlling the behavior of a host of genes and proteins related to diabetes. Spiegelman’s lab discovered the role of PPAR-gamma as a regulator of fat cell development in 1994. The new experimental compounds also target PPAR-gamma, but through a different mechanism discovered this past year.Actos and Avandia are so-called “agonists” of PPAR-gamma. That is, they bind to the molecule, like a key fitting into a lock, and activate it. When activated, PPAR-gamma causes changes in an unknown number of “downstream” genes and proteins. This cascade treats diabetes by improving cells’ response to insulin and helping the body to control blood sugar. However, the researchers believe this series of molecular events initiated by PPAR-gamma agonism also causes the harmful fluid retention, weight gain, and loss of bone density.Until recently, it had been assumed that Avandia and Actos worked exclusively by agonizing PPAR-gamma. But in 2010, Spiegelman and Griffin reported that they had discovered a second, unsuspected effect of the drugs on PPAR-gamma. The TZD drugs, they said, also block a process called phosphorylation, by a molecule known as Cdk5, that modifies PPAR-gamma in a manner that is entirely separate from agonism.  This mechanism, they said, might in fact be more critical to combating diabetes — and, to their surprise, apparently seemed not to cause the worrisome side effects.In the new report, the team describes the development of synthetic small molecules “that bind tightly to PPAR-gamma yet are completely devoid of classical agonism, and effectively inhibit phosphorylation.”These findings suggested that it might be possible to develop new diabetes drugs that work entirely by blocking the phosphorylation of PPAR-gamma, thus separating wanted from unwanted effects.Griffin, who heads Scripps’ Department of Molecular Therapeutics, and his team devised a plan for concocting the prototype drugs. They searched the literature for compounds known to bind with PPAR-gamma, and chose one to serve as a scaffold which they modified in hundreds of ways. The researchers sifted through these modifications until they found several that blocked phosphorylation of PPAR-gamma.The most effective of these candidates, labeled SR1664, was tested in cultured cells and insulin-resistant mice in the Spiegelman laboratory. It was found to have potent anti-diabetic properties but caused no fluid retention or weight gain. When compared with Avandia, SR1664 showed equivalent anti-diabetic effects, confirming the scientists’ hypothesis that diabetes can be treated by drugs that target PPAR-gamma but don’t agonize the molecule.These studies illustrate that the development of entirely new classes of PPAR-gamma-targeted drugs is feasible, concludes Spiegelman, who is the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at Harvard Medical School, and his colleagues.The co-first authors of the paper are Jang Hyun Choi and Alexander Banks in the Spiegelman lab. Support for the research came from the National Institutes of Health.last_img read more

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The pause that brings peace and productivity

first_imgMany of us feel time-pressured, tethered to our smartphones so we can stay on top of work and home responsibilities. It can be tough to step off the daily merry-go-round, put our phones, laptops, and to-do lists aside, and find decent chunks of quiet time to reflect on our lives.In fact, we may not even be sure how.Yet reflection is important; it gives us a chance to pause and figure out what really matters, especially when struggling with a difficult issue professionally or personally, says Joseph Badaracco, the John Shad Professor of Business Ethics at Harvard Business School, in his new book “Step Back: How to Bring the Art of Reflection into Your Busy Life.”“We often get advice to reflect, and we often give the advice to reflect. But what is reflection?” Badaracco asks. “And how do busy people find time to reflect?”To answer this question, Badaracco studied classic works of reflection, including “Meditations” by Roman Emperor Marcus Aurelius, “Spiritual Exercises” by Jesuit order founder Ignatius Loyola, “Essays” by philosopher Michel de Montaigne, as well as many diaries and journals of leaders.“We often get advice to reflect, and we often give the advice to reflect. But what is reflection?”In addition, Badaracco interviewed more than 100 managers, ranging from supervisors to CEOs, from 15 countries to learn how busy men and women today find time for reflection. He found that almost all of them do reflect, but they don’t necessarily rely on long periods of solitude. Instead, they practice the art of reflection “in the cracks and crevices of their everyday lives” to help them make better decisions day by day and problem by problem.Badaracco recommends four design principles for reflection. Like design principles in art and architecture, they don’t explain precisely what to do and when. “That is your call,” he says. What the design principles provide is a template for sound reflection in a hectic world.1: Aim for good enoughFor many of the managers Badaracco interviewed, the biggest obstacle to reflecting was acute time pressure. As one manager said, “I go from commitments at home to commitments at work … I have very little me time.” Others had trouble keeping their thoughts from relentlessly zig-zagging all over the place, or felt restless taking time to sit and think. “I hate feeling idle,” one manager said. “I hate the feeling of not doing anything that I don’t think is productive.”And some resisted reflecting, saying it was easier to focus on the here-and-now, rather than look down the road where they might be forced to grapple with the uncertainty of the future. “It can be a little frightening because, you know, this is the time when I’m supposed to sit down with a pad of paper and really think ahead, and you’d much rather be busy because it’s so easy to focus on the latest emails,” one manager said. “Some of the crazy busyness is self-imposed.”But it doesn’t take ironclad discipline, rigid scheduling, or abandoning the laptop for a full hour to overcome these obstacles. It starts with letting go of the idea that we must reflect in a time-consuming or perfect way; instead, we should “aim for good enough,” Badaracco says. Thoughtful reflection is worth doing, even if we fall short of some ideal—and given the busy pace of our lives, “good enough” reflection is a real accomplishment, he says.How do we aim for good enough? The answer, Badaracco says, is to find an approach that fits comfortably into your life and, even better, involves something you enjoy doing. Some of the managers took advantage of quiet periods when they were doing other things, like exercising, cooking, or commuting to work. “In the car,” one manager said, “I find it really easy to concentrate because there’s nobody talking to me, and you can watch the road, which I think you can do with about half your brain, while the other half is at work.”About a quarter of the managers relied on occasionally writing out their thoughts, in journals and notebooks or even spreadsheets that compared the pros and cons of a problem.And reflection doesn’t have to be a solitary act. Some managers sought out meaningful conversations with trusted others, relying on regular calls to their parents or turning to a colleague who, as one manager said, is “the kind of person you go see when you need to talk something through, so you go to their office and close the door.”2: Downshift occasionallyThe first of the three fundamental approaches to reflection has traditionally been called contemplation, or downshifting from time to time. At work, many people tend to focus on output, and their minds act like race car engines, firing on all cylinders at 200 miles an hour to exert the mental power needed to examine problems, figure out solutions, and get things done.Many of the managers Badaracco interviewed found ways to pause and put their mental machinery into a lower gear, letting their minds unfocus, and resisting the urge to feel continuously productive or decisive. “If something is bothering you about a particular problem, sometimes you have to slow down to recognize it,” Badaracco says.During a work meeting, rather than staying laser-focused on getting through the agenda, take time to look around the room and pay attention: Do coworkers seem interested or bored? Is the conversation heading in the right direction?Badaracco describes a range of approaches interviewees followed and recommends people see what works well for them. One approach suggests mental meandering by letting your thoughts, feelings, and attention wander for a few minutes to see where they go. Look up from your computer screen and take a break from accomplishing task after task.Another suggestion involves simply slowing down physically in order to slow down mentally. One busy executive who managed 1,500 people said when she had meetings away from the office, sometimes she left early to “make my way there slowly” to get a “feel for how things are going.”Other managers turn to nature. One manager, quoting her father, a farmer, said, “The number of people who can walk outside and just look up is so small.” Hitting the beach or a nature trail in the middle of a workday may not be practical, but taking a short walk outside or even looking out the office window or at an indoor plant can help free up the mind.And finally, many interviewees made a conscious effort to take a little time to celebrate progress or successes, rather than staying focused only on their list of to-dos. Some did this by praying and thanking God; others kept a journal of things they are grateful for. Marc Andreesen, the high-profile venture capitalist who helped create the Mosaic Web browser, keeps an “anti-to-do list,” which displays everything he has done during the day to feel a sense of accomplishment, confidence, and motivation to continue.One manager, noting the need to escape what he called the “psychic prison of continuous improvement,” regularly set aside time to celebrate workplace achievements with his staff.“Reflection is often viewed as a gloomy, serious enterprise, where you ask: Where have I failed, and what should I do next?” Badaracco says. “But you ought to look at the full range of things you have already done, including non-work tasks, and pat yourself on the back occasionally.”3: Ponder your hard issuesThe second fundamental approach to reflection is pondering. This means stepping back and consciously looking at a problem from a variety of perspectives.The managers Badaracco interviewed did this in a wide range of ways. Some tried to vividly imagine the everyday consequences of choosing among two different options—such as deciding whether to take a new job or stick with a current one. Some doodled their thoughts, some tried to look at a problem from the perspective of someone they admired or someone who might be badly affected by it, and some tried to see if they had feelings or perspectives on the margins of their minds that they were uncomfortable examining.“Without reflection, we drift.”A few managers even acknowledged that they talked with themselves, sometimes aloud, to see an issue from a wider perspective.“It’s about making a conscious effort to look at things from a variety of viewpoints without trying to crack the case or come up with the answer right away,” Badaracco says.4: Pause and measure upThe third classic approach to reflection involves measuring up. This is particularly relevant when you have to make a decision and act on it. It’s critical to take a few moments to step back and ask yourself which option is best in terms of the standards that others expect you to meet and the standards you have set for yourself, Badaracco says.The managers Badaracco interviewed took different approaches to this way of reflecting. Some imagined what their professional role models would do. Others followed personal principles or mantras that meant a good deal to them, based on earlier experiences in their lives. Some asked themselves what kind of legacy, however modest, they wanted to leave behind before deciding what to do.Reflection promotes growth Reflection, Badaracco says, can enhance your life and your work, if you develop a pattern or mosaic of reflection that meshes with your life and if you occasionally step back further to reflect more deeply.“Without reflection, we drift,” Badaracco says. ”Others shape and direct us. With reflection, we can understand and even bend the trajectories of our lives.”This article originally appeared in Working Knowledge.last_img read more

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Military Forces of Colombia Deal Blow to Residual Organized Armed Group

first_imgBy Myriam Ortega/Diálogo September 22, 2020 In early August, the Colombian Navy and Army dealt a harsh blow to the residual organized armed group (GAO-r, in Spanish) Estructura Sexta, which operates in the Colombian Pacific. In three operations, the Military Forces seized a semisubmersible and 1 ton of marijuana and captured two of the group’s members.Troops from the 24th Marine Riverine Battalion, assigned to the 2nd Marine Brigade, and from the Army’s 2nd Anti-narcotics Battalion found the semisubmersible in the Naya River area. The 30-meter long vessel could carry up to 8 tons of illicit substances, Colombian Marine Corps Colonel José Domingo Cantillo Caro, chief of staff of the 2nd Marine Brigade, told Diálogo. “It’s a naval apparatus built with a particular characteristic, namely that it’s interoceanic; one of these apparatus can easily make it to Mexico, to Central America without a problem, and that’s what stands out,” Col. Cantillo said. “Here in the Pacific, we’ve found improvised shipyards where they build this type of artifact hidden in the mangroves, and little by little they assemble a semisubmersible in about two to three months.”Service members seized more than 680 liters of diesel fuel near the semisubmersible, which suggests that it was ready to be loaded with illicit substances, the Navy said in a statement. The vessel, valued at $1 million, was destroyed in that area, the Navy reported.From January 1 to August 15, 2020, the 2nd Marine Brigade seized four semisubmersibles, 5,900 kilograms of marijuana, and some 8 tons of cocaine hydrochloride, and captured 14 individuals, all from Estructura Sexta, Col. Cantillo said.Authorities dealt another blow to the GAO-r during a raid in Valle del Cauca department, when Army elements captured two members of an Estructura Sexta column. The Army reported that the detainees, alias Negro and alias Mechas, managed the largest drug warehouse in the area.On site, authorities also found a vehicle containing 774 kg of marijuana, the Army said. During another raid against the GAO-r in Cauca department, Army units found 18 packages containing 270 kg of marijuana.last_img read more

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First look at Gold Coast property selling season

first_img79-81 Commodore Drive, Paradise Waters was one of 17 lots to go to auction. Photo: supplied by Diakrit.LUXURY homes and development sites have gone under the hammer in one of the first Gold Coast auction events.A stable of 17 properties were up for auction at the Amir Mian Prestige Property Agents Auction Showcase at the Palazzo Versace. Amir Mian auction showcaseDespite up to 25 registered bidders for the event and a diverse range of property stock, just one property sold under the hammer. Bidding on a suburban Southport residence started at $400,000 before it was called on the market and sold for $610,000. The two-storey residence features a Mediterranean inspired guest house. 33 Palm Ave, Surfers Paradise attracted plenty of Chinese buyer interest.Bidding on a vacant lot at Surfers Paradise inched slowly along, with one bidder offering increments of $1000, before it was ultimately held over at $800,000.“At that site, the bidders are at $800,000 and the sellers are at $950,000 so it’s close,” said Mr Mian, who will now assist negotiations behind closed doors for the 16 remaining properties.“In the next fourteen days we will see where we end up, hopefully there is a medium somewhere.” More from news02:37Purchasers snap up every residence in the $40 million Siarn Palm Beach North1 hour ago02:37International architect Desmond Brooks selling luxury beach villa21 hours agoIt was called on the market at $610,000.“The positive is that 90 per cent of the properties had bidders,” principal Amir Mian said,“Bidders are around five to 10 per cent shy from where the sellers are, so sellers are digging their heels in and so are the buyers.”Mr Mian had said his event would be a “litmus test” of the current Gold Coast property market and how it would move in 2018.“Two things can happen from here next year, either buyers will come up and meet the sellers, or the sellers have to adjust to the market,” he said.“What the sellers need to do now is look at where the market is.” It offers spacious living with river and skyline views.But Mr Mian said the event showed an improvement in bidder activity compared to the last six months.“On the development and land lots, the majority of bidders were Chinese,” he said, “Around 20 per cent of them were from interstate, we had someone from Canberra, we had someone from Melbourne, we had someone from Sydney.”The team is now preparing for another auction showcase in January, planned to coincide with the end of school holidays, interstate market interest and the Chinese New Year. 18 Egerton St, Southport was the sole property to sell under the hammer.last_img read more

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Teens who vape or use hookah are more likely to use marijuana later, study finds

first_imgCNN News 6 August 2018Teens who used e-cigarettes and hookah were up to four times more likely to use marijuana later, according to a study published Monday in the journal Pediatrics.Researchers from the University of Pennsylvania and the University of Southern California surveyed 2,668 students at 10 public high schools in Los Angeles beginning in fall 2013, when they were 14 years old and in ninth grade. The students answered a paper-and-pencil, phone or internet survey that asked whether they had ever used (or had used in the past 30 days) e-cigarettes, combustible cigarettes or a hookah water pipe. They were also asked whether they had used any type of marijuana product. The use of less popular tobacco products such as smokeless tobacco and cigars was not studied.In a followup survey in fall 2015, when the students were 16 years old and in 11th grade, the survey asked whether they had used three types of marijuana products: combustible, vaped or edible. The researchers found that the students who had tried e-cigarettes when they were freshmen had a more than three-fold greater likelihood of ever using marijuana and using marijuana in the past 30 days than students who hadn’t tried e-cigs.“When we were thinking about this topic, we were kind of just reflecting on the fact that we have more tobacco products on the market now than ever,” said Janet Audrain-McGovern, an associate professor in the Department of Psychiatry at the University of Pennsylvania’s Perelman School of Medicine and lead author of the study. “And we’ve seen cigarette smoking decline among young people, but we’ve seen increase in use of these other tobacco products. At the same time, we’ve also seen in many areas of the country a lessening of the restrictions surrounding marijuana use.”READ MORE: https://edition.cnn.com/2018/08/06/health/vape-hookah-marijuana-teens-study/index.htmllast_img read more

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Lady Bulldogs Weekend Softball Results

first_imgThe Batesville Lady Bulldogs came up short against The Rushville Lady Lions in Varsity play 5-3 and 18-4 in JV action on Friday (5-8).BHS vs. Rushville Varsity Softball (5-8)BHS vs. Rusjville JV Softball (5-8)The Lady Bulldogs dropped the doubleheader games with The Greenfield Central Cougars 7-0 and 4-1.BHS vs. GFC-Game 1 (5-9)BHS vs. GFC-Game 2 (5-9)Batesville will return to action on Monday (5-11) at Rising Sun to battle The Lady Shiners.  1st Pitch will be at 5:30 PM.Courtesy of Bulldogs Coach Jody Thomas.last_img read more

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Bulldogs Strong Showing At EIAC Track Meet

first_imgIt was a perfect night for a track meet! Temperature was great, not much wind, and no rain in site! The Batesville Bulldogs took advantage of it and had some incredible performances.The guys captured the Conference Title as they outscored theiropponents by just over 20 points and continue their undefeated season. The Bulldogs put together a score of 155 points to Rushville’s 134.5. East Central was third with 87, followed by Connerville-65, Franklin County 51, Greensburg 46, South Dearborn 43and Lawrenceburg 24.Despite some adversity on the girls side and finding out this week that 3 varsity girls would be out because of injury, the other girls stepped up their game and put together some awesome performances. Seeded to receive 3rd place, the lady Bulldogs were just 3 points shy of a conference championship and proudly accept the runner up honors. Just outscoring the Bulldogs were the East Central Trojans with 134 points to Batesville’s 131. (Batesville was only seeded to score 112 points!) They were followed by Greensburg with 127.5, Connersville 80.5, Franklin County 52.5, Rushville 50.5, South Dearborn 21.5 and Lawrenceburg 8.5.  BBatesville also proudly claimed the guys MVP awardgiven to Peter Heil! Peter had a stellar night winning in all 3 of his individual events, the 110 hurdles with a personal best of 15.43, the 300m hurdles, also with a personal best of 40.21, the long jump with another personal best of 20’9.25″ and was a part of the 4 x 400 relay which ran a personal best of 3:30 and coming in second place by 1/2 a second.Batesville also had some other individual conference champions on the night. They were: Connor Bell in the 800m run (2:03.55),Clare Bruns in the 300m hurdles with a PR (49.10), Kelsey Gausman in the 800m run (2:28.37), the boys 4 x 800 team of Garrett Yorn, Caleb Moster, Cole Nuhring and Connor Bell, both the boys and girls 4 x 100m relay of Jacob Koehne, Tanner Ayette, Garrett Yorn, Michael Tunny and Madeleine Robben, Haylee Harmeyer, Mary Elizabeth Elkins, Clare Bruns, and the girls 4 x 400m relay of Haylee Harmeyer, Madeleine Robben, Mary Elizabeth Elkins and Clare Bruns with a PR (4:13.00).Just missing out as Conference Champions by less than a second, but breaking their own school record by another 3.5 seconds was the girls 4 x 800 team of Mary Poltrack, Maria Wessel, Sarah Poltrack and Kelsey Gausman. (10:07.32).Batesville also had several other runner up awards to hand out and they went to:Clare Bruns-100m hurdlesTanner Ayette-100m dash and 200m dashMichael Tunny-400m dashMary Elizabeth Elkins-400m dash and long jumpMadeleine Robben-200m dashCaleb Moster-3200m runMary Poltrack-3200m runSamantha Heidlage-shot putBoys 4 x 400 team of Garrett Yorn, John Moody, Peter Heil and Michael Tunny3rd place finishers were:Caleb Moster-1600m runJohn Moody-400m dashAlison Muckerheide-long jumpKevin Bedel-high jump4th place went to:Jessica Wagers-pole vaultLuke Forbeck-discusTimothy Tunny-high jump5th place finshers were:Haylee Harmeyer-100m dash and 200m dashGrant Meyers-1600m runKelsey Gausman-1600m runGarrett Wagner-300m hurdlesCole Nuhring-800m runMichael Tunny-200m dashScoring in 6th place:Samantha Heidlage-discusKevin Bedel-discusMaria Wessel-3200m runChris Riffle-3200m runMaddie Pierson-400m dashSarah Poltrack-1600m runJacob Koehne-100m dashGarrett Wagner-110m hurdlesThere were no 7th place finishers for Batesville, but finishing out the scoring in 8th place were:Emma Gausman-800m runRobert Strobel-pole vaultAvni Patel-shot putAgain, as the weather was beautiful for a track meet, there were a plethora of personal records turned in by the Bulldogs and they were:110/100m hurdles-Peter Heil and Clare Bruns100m dash-Tanner Ayette200m dash-Madeleine Robben, Haylee Harmeyer300m hurdles-Peter Heil and Clare Bruns400m dash-Mary Elizabeth Elkins800m run-Emma Gausman1600m run-Caleb Moster and Grant Meyers3200m run-Chris Riffle, Mary Poltrack and Maria WesselLong Jump-Peter Heil, Alison MuckerheideShot Put-Avni PatelDiscus-Luke Forbeck4 x 800 splits of Mary Poltrack and the whole team’s total time4 x 400 splits of Garrett Yorn, Madeleine Robben and Clare Bruns as well as both team’s (boys and girls) total team timeThe Bulldogs are looking strong as both teams now head into Sectional competition next week. The girls compete Tuesday at Franklin County and the boys’ Sectional is Thursday at East Central. Best of luck!The JV Track and Field team will finish out their season this Saturday as they compete in the JV Conference meet at South Dearborn. Action begins at 10am.Courtesy of Bulldogs Coach Lisa Gausman.last_img read more

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West Ham defender Zabaleta wants to retire at Espanyol

first_img “I am quite clear that I am leaving England when my contract with West Ham ends – then I will make a decision personally and professionally,” Zabaleta told Radio Continental, via La Razon. Read Also: Valencia seek loan move for Chelsea goalkeeperHe then moved to West Ham in 2017 on a free transfer where he has clocked up 80 matches to date, but has featured in just 10 Premier League matches so far this campaign.The full-back won 58 caps for Argentina but has not been involved in the international setup since 2016.FacebookTwitterWhatsAppEmail分享 West Ham defender Pablo Zabaleta wants to return to Espanyol this summer as a free agent to play for the club again before he retires. The 35-year-old spent three seasons at the Catalan club between 2005 and 2008 after his move from San Lorenzo, helping them to the Copa del Rey title in 2006 and UEFA Cup – where they lost to Sevilla on penalties – the following year.Advertisement Promoted Content2020 Tattoo Trends: Here’s What You’ll See This Year5 Of The World’s Most Unique Theme ParksWhat Is A Black Hole In Simple Terms?7 Ways To Understand Your Girlfriend Better10 Risky Jobs Some Women Do7 Universities In The World With The Highest Market Value5 Of The World’s Most Unique Theme ParksWho’s The Best Car Manufacturer Of All Time?Who Is The Most Powerful Woman On Earth?Birds Enjoy Living In A Gallery Space Created For ThemBest & Worst Celebrity Endorsed Games Ever MadeSome Impressive And Almost Shocking Robots That Existcenter_img “We want to live with my family in Barcelona. Now I am at that stage when you have days that you think about going on for a couple of years or sometimes when a boy in training ruins and you think about retiring.” Zabaleta is most well known for his nine-year stint at Manchester City after he left Catalonia – helping the club to win two Premier League titles in 2012 and 2014, making 333 first-team appearances under various managers. Loading… last_img read more

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Wenger backs Theo to bounce back

first_imgArsenal manager Arsene Wenger is in no doubt that England forward Theo Walcott has the character to return “as strong as ever” from the knee injury which shattered his World Cup dream. Wenger, though, is confident Walcott’s “balanced” personality can help him recover fully from such a devastating setback. “Theo is handling it as well as you can when you have had such a shock because he is mentally strong, is very balanced as a person and he can put it into perspective,” Wenger said on Arsenal Player. “We know that he will have the dedication and the serious attitude to come back as strong as ever.” Wenger added: “He has surgery and then it’s rehab. You know that it is six months and that you hope it all goes well. The only thing I can say is it’s very sad news for us and above all for him.” Despite Wenger’s positive rhetoric for the future, the Gunners boss concedes the serious injury to Walcott removes a potent weapon in his team’s attack, with the former Southampton man having netted five goals since his return from a stomach injury. “We lost a very talented player, a very intelligent player and a player who was just grabbing his form again,” the Arsenal manager continued. “From game to game he became more influential, you have seen a complete player. “He can always decide a game through a final ball or through a goal. Sometimes in the same game he does both. The 24-year-old is set to be sidelined for six months after suffering anterior cruciate ligament damage when making a defensive tackle in the FA Cup third-round win over Tottenham on Saturday. Walcott’s loss is a major blow for both club and country, with the pacy forward set to have been a key part of England manager Roy Hodgson’s plans in Brazil this summer. “I felt against Tottenham he had a very convincing performance because he integrates well our style of play as he has been here for so many years now. “When we combine at a high pace he is involved in it because he understands exactly what we want to do.” Arsenal will now have to plan for the rest of the campaign without the electric pace of Walcott, but the imminent return of Alex Oxlade-Chamberlain from his own five-month lay-off with a knee injury and the emergence of German starlet Serge Gnabry – said to have sparked interest from Borussia Dortmund – does provide Wenger with options. Wenger said: “It has been five months where he has been completely out, so that means he is fresh and that should give us a boost.” Arsenal are understood to be looking to bring in back-up for lead striker Olivier Giroud during the transfer window, although Wenger concedes pushing through a big-money transfer such as Atletico Madrid’s Diego Costa – at this time of the season – is historically difficult. “[Walcott’s injury] has accelerated speculation first and of course my desire as well – but let’s not forget about Serge Gnabry who can play in the first team,” the Arsenal manager added. “We have Oxlade-Chamberlain back and we have many other players who can play on the flanks so to find better solutions than what we have internally will not be easy. “Up front we lose Theo as a potential central forward and that’s maybe where we have to look outside, but we hopefully have (Nicklas) Bendtner back in three weeks. “We are there for the opportunities, but it is very difficult at the moment.” Wenger revealed midfielder Aaron Ramsey and defender Kieran Gibbs were “very close” to making comebacks, although captain Thomas Vermaelen is doubtful because of a knee injury sustained in the FA Cup tie against Spurs. Arsenal could be usurped at the top of the table by title rivals Chelsea and then Manchester City before they kick off at Aston Villa on Monday night. Midfielder Tomas Rosicky, however, maintains the Gunners have the maturity to last the distance through to May. “This team has more experience than it did in the past. We have [Per] Mertesacker – and[Mesut] Ozil, who won things in Madrid – and the other experienced boys like Mikel [Arteta] and [Mathieu] Flamini,” the Czech playmaker said. “Plus the English boys are not kids anymore, they gained experience through the years of playing here, so that is why I think we have the maturity to do it this year.” Press Associationlast_img read more

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Moyes men frustrate Gunners

first_imgArsenal were denied a return to top spot in the Barclays Premier League after Manchester United battled to a goalless draw at the Emirates Stadium. Chances were at a premium between the two sides, with the best coming in the opening minutes as former Arsenal captain Robin van Persie, now in the United camp, and home striker Olivier Giroud should both have scored. Arsenal goalkeeper Wojciech Szczesny pushed a bullet header from the Holland forward against the crossbar in the second half of a match which ultimately failed to live up to its billing, leaving Jose Mourinho’s Chelsea still top of the league. Press Association Arsenal were looking to return to the top of the table following Chelsea’s draw at West Brom, and boss Arsene Wenger made two changes in the wake of the 5-1 mauling at Liverpool, with Tomas Rosicky and Kieran Gibbs starting. Wenger’s men had been caught sleeping by Liverpool’s fast start on Saturday, and they were almost behind within the opening minute again, as they were at Anfield, when Arteta gave the ball away on the edge of the penalty area. However, Van Persie, so prolific in the season before he left the Emirates Stadium, scuffed his shot and Szczesny got down to save. Arsenal then went on the offensive, with a goal-bound shot from Jack Wilshere blocked before Giroud headed wide from five yards following the resulting corner. A 20-yard strike from Rosicky spiralled up off the back of United captain Nemanja Vidic, who is set to leave at the end of the season, and almost wrong-footed goalkeeper David De Gea. Van Persie beat the offside trap after 17 minutes down the left channel, but then made a complete hash of his cross, which flew through the penalty area and out of play on the far side. The tempo of the match dropped before Giroud cracked a 20-yard effort high and wide following a good spell of Arsenal pressure. There was a brief stoppage when home left-back Gibbs needed treatment following a heavy fall after making a header in the United box – which left Red Devils manager Moyes fuming after play was correctly called back by referee Mark Clattenburg. United’s Brazilian full-back Rafael then also had to be treated after coming off worse in a 50/50 challenge with Giroud. Cazorla crashed a 20-yard shot into the back of Wilshere as the first half fizzled out. United were forced into a change at the start of the second half as struggling Rafael was replaced by Rio Ferdinand, who made his first Premier League appearance since November. Having been frustrated by United’s determined midfield display, Arsenal almost snatched the lead after 61 minutes when Valencia’s headed clearance under the crossbar thwarted Koscielny. Szczesny was then quick off his line to head clear as Van Persie closed in on the Arsenal penalty area. Both sides made a change as the match entered the final 15 minutes, as United replaced Juan Mata with Adnan Januzaj and Arsenal midfielder Alex Oxlade-Chamberlain came on for Rosicky. Arsenal were close again when Sagna’s right-wing cross was just ahead of Giroud as he raced in at the near post. With 10 minutes left, Van Persie could have won it when he met a floated cross from Rooney at the far post with his powerful header, from which Szczesny produced his heroics. There was time for De Gea and Cazorla to have their personal battle in the late stages, but neither side had really done enough to earn victory. David Moyes’ visitors were almost gifted a lead inside the first minute when Mikel Arteta gave the ball away to Van Persie, but the one-time Arsenal skipper saw his scuffed shot saved. French forward Giroud headed an Arsenal corner wide from inside the six-yard box in what was an electric start. However, the tempo of the match then dropped, with only a deflected effort from Tomas Rosicky causing United goalkeeper David De Gea some concern during the lull. United – looking to make up ground on the top four following their 2-2 draw at home with Fulham – continued to frustrate Arsenal with a determined midfield display, closing down space quickly when not on the ball. When Arsenal did get into second gear as the hour passed, Antonio Valencia cleared a header off the line from Arsenal defender Laurent Koscielny. Giroud just could not get on the end of a great cross from right-back Bacary Sagna before, at the other end, Szczesny tipped a bullet header from Van Persie against the frame of the goal. De Gea twice saved from Santi Cazorla during the closing stages as Arsenal pressed for a winner, but each team had to be content with a point. United made two changes following the disappointment of the Fulham result, as Tom Cleverley and Valencia came in, while midfielder Marouane Fellaini was on the bench following a long lay-off with a groin problem. last_img read more

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